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Creators/Authors contains: "Ge, Chutian"

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  1. ; ; ; ; ; ; (, Science)
    null (Ed.)
    In many reptiles, including the red-eared slider turtle Trachemys scripta elegans ( T. scripta ), sex is determined by ambient temperature during embryogenesis. We previously showed that the epigenetic regulator Kdm6b is elevated at the male-producing temperature and essential to activate the male pathway. In this work, we established a causal link between temperature and transcriptional regulation of Kdm6b . We show that signal transducer and activator of transcription 3 (STAT3) is phosphorylated at the warmer, female-producing temperature, binds the Kdm6b locus, and represses Kdm6b transcription, blocking the male pathway. Influx of Ca 2+ , a mediator of STAT3 phosphorylation, is elevated at the female temperature and acts as a temperature-sensitive regulator of STAT3 activation. 
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  2. ; ; ; ; ; ; ; ; (, Science)
    null (Ed.)
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